Scottsdale TMS Therapy has expanded its interventional psychiatry services with the addition of Spravato, an esketamine nasal spray treatment, for adults in the Southwest who have not responded to traditional antidepressant medications. The clinic, located in Old Town Scottsdale, Arizona, is now offering esketamine therapy alongside its existing transcranial magnetic stimulation (TMS) protocols to treat complex mood disorders through neurological approaches.

Patients with treatment-resistant depression often wait four to six weeks for conventional oral antidepressants to produce measurable effects, which can leave them in an extended cycle of medication changes and adjustments. Esketamine is an FDA-approved medication that works through a different mechanism, targeting NMDA receptors to support neuroplasticity, the brain’s ability to form new neural connections and restore circuits involved in emotional regulation. Spravato is administered in a certified medical setting because it can cause sedation, dissociation, and changes in blood pressure that require observation after dosing.

According to a spokesperson for Scottsdale TMS Therapy, the treatment approach can reduce depressive symptoms and suicidal ideation within days, providing a more immediate option for patients who have not responded to two or more standard antidepressant trials.

The clinic said adding esketamine broadens its advanced interventional psychiatry offerings in an outpatient setting. By focusing on biological factors associated with major depressive disorder, Scottsdale TMS Therapy is positioning the service as an alternative for patients who have exhausted conventional treatment options. The expansion also reflects a broader shift in depression care toward clinic-based treatments that target brain circuits and neurotransmitter systems beyond the serotonin pathways associated with many first-line antidepressants.

Scottsdale TMS Therapy operates as a fully REMS-certified facility, which means it meets federal safety and monitoring requirements for the treatment. Sessions are conducted under the supervision of board-certified psychiatrists and master’s-level clinicians. Each appointment includes pre-treatment health screenings, supervised self-administration of the medication, and a required two-hour observation period after treatment, with continuous monitoring of blood pressure and other vital signs.

The Scottsdale facility also includes Apollo TMS chairs, private treatment rooms, an on-site cafe, and an outdoor patio, features intended to support patient comfort, reduce stress, and provide emotional safety during visits.

The clinic works with major commercial payors, accepts most insurance plans, and manages the full authorization process internally. Individuals seeking information about interventional treatment options for severe major depressive disorder can contact Scottsdale TMS Therapy’s clinical admissions team for confidential consultations and same-day insurance verification.